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. 2018 Jul 19;8:10955. doi: 10.1038/s41598-018-29339-0

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Genomic methylation patterns. (A) Hypo- and hypermethylation peak counts obtained from three cell lines in each group. EG-4F-iPSC versus 4F-iPSC peaks were considered as hypermethylation peaks; 4F-iPSC versus EG-4F-iPSC peaks were considered as hypomethylation peaks. (B) Average proportions of peaks within each region as defined by genomic structure. *P < 0.05 (C) Average proportions of peaks within each region as defined by distance from the CpG island. (D) Enrichment analysis of hypomethylated genes covered with peaks. (E) Comparison of imprinted gene expression in EG-4F-iPSCs and 4F-iPSCs as quantified by mRNA expression. Error bars indicate standard error of the mean (n = 3). Results were normalized to human histone H2A.Z (H2AFZ) expression. (F) Bisulfite sequencing of Nanog and OCT4 promoter region. Black circles represent methylated sites, white circles represent unmethylated sites. Global methylated cytosines are shown as %M.