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. 2018 Jul 19;8:10954. doi: 10.1038/s41598-018-29262-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Enforced GPR68 stimulation inhibits IL-22 and IL-10 production from human CD4 T cells. Naïve CD4 T cells were cultured with Th17-inducing cytokines (Th17) for six days in the presence or absence of FICZ or CH223191, as indicated. Experimental groups were treated with (open bars) or without (closed bars) ogerin. On day 6, IL-22 (A), IL-10 (B), IL-17 (C) and IFN-γ (D) were measured in culture supernatants. Shown are the Mean+/− SEM from four experiments with n = 8.