Table 1.
Most common cellular functions for genes differentially expressed by each condition relative to Th17 treatment.
| Media | p-values | Th17 + FICZ | p-values | Th17 + CH223191 | p-values | |||
|---|---|---|---|---|---|---|---|---|
| Cell function | Genes | Cell function | Genes | Cell function | Genes | |||
| Cell death and survival | 319 | 4.6 × 10−42 – 1.9 × 10−5 | Small molecule biochemistry | 10 | 7.8 × 10−6 – 5.0 × 10−2 | Cellular assembly and organization | 18 | 5.9 × 10−5 – 9.0 × 10−3 |
| Gene expression | 223 | 1.3 × 10−16 – 9.6 × 10−6 | Lipid metabolism | 5 | 7.8 × 10−6 – 3.3 × 10−2 | Cellular development | 15 | 2.0 × 10−5 – 8.9 × 10−3 |
| Cell cycle | 168 | 9.7 × 10−14 – 2.0 × 10−5 | Nucleic acid metabolism | 3 | 2.2 × 10−4 – 2.8 × 10−2 | Cell cycle | 14 | 5.9 × 10−5 – 9.2 × 10−3 |
| Protein synthesis | 108 | 3.0 × 10−22 – 9.6 × 10−6 | Vitamin and Mineral Metabolism | 3 | 1.6 × 10−4 – 3.6 × 10−2 | Cellular growth and proliferation | 14 | 3.0 × 10−5 – 9.2 × 10−3 |
| RNA post-transcriptional modification | 60 | 1.2 × 10−22 – 2.2 × 10−6 | Drug metabolism | 2 | 2.4 × 10−5 – 2.8 × 10−2 | Cell morphology | 10 | 2.0 × 10−5 – 8.9 × 10−3 |
Numbers of differentially expressed genes in functional categories, identified by Ingenuity Pathway Analysis. This platform reports p-values for the overlap of specific subcategories of each functional category under the null hypothesis that the set of differentially expressed genes is independent of the subcategory. The range of p-values over these subcategories is indicated.