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. 2018 Jul 19;9:2827. doi: 10.1038/s41467-018-05154-z

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — CTC1-STN1 binds ssDNA and ss-dsDNA junctions with reduced affinity. a EMSAs showing CST, CS, or ST binding to 18 or 36 nt telomeric G-strand (Tel-18, Tel-36) or 48 nt non-telomeric (NonTel-48) ssDNA substrates. Reactions contained 0.1 nM DNA and the indicated concentrations of protein. b EMSAs showing CST, CS, or ST binding to ss-dsDNA telomeric junction substrate with 10 nt 3ʹ overhang, same substrate lacking the overhang or 10 nt ssDNA of same sequence as the overhang. Black line: non-telomeric, gray: telomeric sequence; fb fold-back