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. 2018 Jul 19;8:10906. doi: 10.1038/s41598-018-29317-6

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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A schematic illustration of the key findings of this article. (A) In the cervical loop of the wild type incisors, Runx1 regulates Stat3 phosphorylation, which further regulates the expression of Lgr5 and enamel matrix protein. (B) In the Runx1 mutant incisors, Stat3 phosphorylation was significantly disturbed with the downregulated expression of Lgr5 and enamel matrix proteins. (C) The pharmaceutical Inhibition of Stat3 signaling resulted in the significant downregulation of Lgr5 and enamel matrix proteins. (D) Pharmaceutical Stat3 activation upregulated the expression Lgr5 and enamel matrix proteins in Runx1 mutants.