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. 2018 Jul 19;8:10907. doi: 10.1038/s41598-018-29367-w

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Partial cluster-specific ECLIPSE response models. a Density estimation of cell scores distribution of patients #63 and 67 grouped in the green cluster; b Density estimation of cell scores distribution of patients #49 and 68 grouped in the blue cluster; c Density estimation of cell scores distribution of patients #65, 30, 46, 66, 78 and 29 grouped in the red cluster; d Density estimation of cell scores distribution of patient #48 (black individual). Both axes report the variance explained in total for the patients of each group by the respective PCs of the partial cluster-specific ECLIPSE Models. The 4 models are qualitatively comparable in terms of percentage of variance explained. However, great difference in the loadings indicates that the type of variation accounted by each model is non-identical: each patient cluster is defined by a different and characteristic combination of cell populations.