Fig. 2.

Synthesis of α-amino amides. a Scope with respect to the tertiary amide. b Scope with respect to the isocyanide. Standard condition: amide 0.3 mmol, IrCl(CO)(PPh₃)₂ 1 mol%, TMDS 0.6 mmol, CH₂Cl₂ 3 mL, isocyanide 0.6 mmol, CH₃COOH 0.36 mmol; yields of purified product following flash column chromatography; ^areaction was performed at 50 °C after the addition of tert-butyl isocyanide and CH₃COOH; ^bwith 0.9 mmol CH₃COOH