Fig. 5.

Synthetic application. a Late-stage functionalization of bioactive molecules and derivatives using amide reductive Ugi-type reactions. b Synthesis of bioactive molecules via reductive Ugi-type reactions followed by hydrogenation. Standard condition: amide 0.3 mmol, IrCl(CO)(PPh₃)₂ 1 mol%, TMDS 0.6 mmol, CH₂Cl₂ 3 mL, isocyanide 0.6 mmol, CH₃COOH 0.36 mmol or trimethylsilyl azide 0.6 mmol; yields of purified product following flash column chromatography