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. 2018 Jul 19;8:10960. doi: 10.1038/s41598-018-27934-9

Table 1.

Electrocardiogram parameters measured in both control and hyperthyroid heart disease rats treated with different sizes of Au-NPs.

Group 0 nm 5 nm 40 nm 100 nm
P-R segment duration (ms) Ctrl 44.10 ± 1.79 44.67 ± 0.95 49.67 ± 1.41 44.00 ± 2.70
HHD 39.00 ± 3.35 36.33 ± 2.32 40.29 ± 1.67 41.60 ± 1.17
QTc (ms) Ctrl 130.12 ± 4.47 120.30 ± 11.77 113.11 ± 7.07* 129.22 ± 11.86
HHD 151.02 ± 11.28§ 142.06 ± 12.15 140.27 ± 5.96 149.82 ± 8.51
P wave duration (ms) Ctrl 16.20 ± 0.63 19.67 ± 2.22* 16.83 ± 0.98 15.60 ± 2.20
HHD 12.00 ± 0.55§§ 12.17 ± 0.83 13.29 ± 0.75 12.60 ± 1.29
P wave amplitude(mV) Ctrl 0.057 ± 0.00396 0.0567 ± 0.0042 0.07 ± 0.00966 0.058 ± 0.01068
HHD 0.1120 ± 0.01356§§§ 0.0667 ± 0.00989* 0.0643 ± 0.01251* 0.08 ± 0.00837
P (mV)/P(ms) Ctrl 0.0036 ± 0.00030 0.0032 ± 0.00052 0.0043 ± 0.00066 0.0041 ± 0.00099
HHD 0.0096 ± 0.00145§§§ 0.0056 ± 0.00085* 0.0051 ± 0.00123* 0.0065 ± 0.00074
Q wave amplitude(mV) Ctrl 0.0210 ± 0.00504 0.0217 ± 0.00543 0.0167 ± 0.00422 0.018 ± 0.002
HHD 0.054 ± 0.02227§ 0.0333 ± 0.00558 0.0240 ± 0.00245 0.05 ± 0.01304
QRS duration(ms) Ctrl 25.70 ± 3.89 22.17 ± 1.33 21.17 ± 0.60 21.60 ± 0.60
HHD 24.40 ± 2.89 22.33 ± 1.65 19.14 ± 1.01* 20.60 ± 1.57
R wave amplitude(mV) Ctrl 0.567 ± 0.04387 0.3433 ± 0.07877* 0.4483 ± 0.07414 0.42 ± 0.02
HHD 0.42 ± 0.12946 0.5067 ± 0.05548 0.4671 ± 0.078 0.65 ± 0.08
S wave amplitude(mV) Ctrl 0.138 ± 0.02235 0.2533 ± 0.08019 0.1517 ± 0.04826 0.274 ± 0.05446*
HHD 0.286 ± 0.07305§ 0.1217 ± 0.03928* 0.1186 ± 0.04554* 0.04 ± 0.03808*
R(mV)/S(mV) Ctrl 4.91 ± 0.68 2.46 ± 0.79 8.66 ± 4.45 2.60 ± 1.16
HHD 2.11 ± 0.86 7.45 ± 2.71 17.16 ± 10.74 19.76 ± 10.39
T wave amplitude(mV) Ctrl 0.075 ± 0.02001 0.0533 ± 0.02472 0.0617 ± 0.01327 0.082 ± 0.02417
HHD 0.03 ± 0.03 0.0233 ± 0.01783 0.0157 ± 0.0173 0.044 ± 0.004
T wave duration(ms) Ctrl 23.67 ± 2.96 28.67 ± 7.88 30.33 ± 1.86 28.67 ± 11.92
HHD 36.33 ± 3.18§ 18.67 ± 2.19** 31.33 ± 10.48 31.67 ± 3.76
T (mV)/T(ms) Ctrl 0.0021 ± 0.00069 0.0015 ± 0.00121 0.0021 ± 0.00037 0.0017 ± 0.00093
HHD 0.0012 ± 0.00138 0.0011 ± 0.00104 0.0004 ± 0.00052 0.0014 ± 0.00015

Intra-group significance, *P < 0.05, **P < 0.01, ***P < 0.001; Inter-group group significance, §P < 0.05, §§P < 0.01, §§§P < 0.001; n = 6.