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. 2018 Jul 13;12:58. doi: 10.3389/fnana.2018.00058

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Copyright © 2018 Wallrafen and Dresbach.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mover colocalization with presynaptic markers vesicular glutamate transporter 1 (vGluT1) and vesicular γ-aminobutyric acid (GABA) transporter (vGAT) in the mouse hippocampus. Immunofluorescence triple labeling of the mouse hippocampus. (A–C) Overview showing the heterogeneous mover expression pattern (A) and the corresponding vGluT1 (B) and vGAT staining (C). (D–I) Overlay of mover (magenta) and vGluT1 staining (green, upper panel) and mover (magenta) and vGAT (green, lower panel) in regions of the hippocampus where mover immunofluorescence was above average. (D) High colocalization of mover with vGluT1 in polymorph layer of DG, low colocalization of mover with vGAT. (E) High colocalization of mover with vGluT1 in stratum radiatum of CA3, low colocalization of mover with vGAT. (F) High colocalization of mover with vGluT1 in stratum lucidum of CA3, low colocalization of mover with vGAT. (G) High colocalization of mover with vGluT1 in stratum oriens of CA3, low colocalization of mover with vGAT. (H) High colocalization of mover with vGluT1 in stratum radiatum of CA1, low colocalization of mover with vGAT. (I) High colocalization of mover with vGluT1 in stratum oriens of CA1, low colocalization of mover with vGAT. (J) Visualization of the quantification of colocalization with the different markers using the Pearson’s correlation coefficient. Bars show average ± SEM; ***P < 0.001. PmL, polymorph layer of dentate gyrus; SR, stratum radiatum (of either CA3 or CA1); SLu, stratum lucidum of CA3; SO, stratum oriens (of either CA3 or CA1). Scale bar: (A–C) = 500 μm, (D–I) = 10 μm.