Table 1.
Expression profiles of podocyte-specific marker proteins known as determinants of cell specificity as suggested by Shankland et al. (26).
| Protein name | Gene name | Cultured Human Podocyte Proteome (45) | Cultured Mouse Podocyte Proteome (26) | ||
|---|---|---|---|---|---|
| 33°C | 37°C | 33°C | 37°C | ||
| CYTOSKELETAL PROTEINS | |||||
| Myosin-2 | MYH2; MYHSA2 | – | – | – | – |
| Podocalyxin | POD+L | + | + | + | + |
| Synaptopodin | SYNPO | + | + | + | + |
| Alpha-actinin-4 | ACTN4 | + | + | + | + |
| BASEMENT MEMBRANE PROTEINS | |||||
| Integrin alpha-3 | ITGA3 | + | + | + | + |
| Integrin beta-1 | ITGB1 | + | + | + | + |
| Integrin-linked protein kinase | HEL-S-28; ILK | + | + | + | + |
| SLIT DIAPHRAGM PROTEINS | |||||
| CD2-associated protein | CD2AP | + | + | + | + |
| Nephrin | NPHS1 | – | – | – | – |
| Cytoplasmic protein NCK1 | NCK1 | + | + | + | + |
| Cytoplasmic protein NCK2 | NCK2 | + | + | + | + |
| Podocin | NPHS2 | – | – | – | – |
| Short transient receptor potential cation channel 6 | TRPC6 | – | – | – | – |
| MEMBRANE PROTEINS | |||||
| Type-2 angiotensin II receptor | AGTR2 | – | – | – | – |
| T-lymphocyte activation antigen CD80 (Activation B7-1 antigen) | CD80 | – | – | – | – |
| P-Cadherin | CDH3 | – | – | – | – |
| OTHER | |||||
| Transcription factor 21 (podocyte-expressed 1) | TCF21 (POD1) | – | – | – | – |
| Transforming growth factor beta-1/2 | TGFB1/2 | + | + | + | + |
| Vascular endothelial growth factor A | VEGFA | – | – | – | – |
| Wilms tumor protein 1 | WT1 | – | – | – | – |
Respective proteins are either marked as expressed (“+”) or not expressed (“–”) in the two examined cell culture conditions (33°C = undifferentiated, and 37°C = differentiated cells). According to Schroeter et al. (45).