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. 2018 Jul 13;9:1590. doi: 10.3389/fimmu.2018.01590

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Copyright © 2018 Trend, Jones, Cha, Byrne, Geldenhuys, Fabis-Pedrini, Carroll, Cole, Booth, Lucas, Kermode, French and Hart.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum concentrations of IgG subclasses, (A) IgG1, (B) IgG2, (C) IgG3, and (D) IgG4 from healthy controls (HC) averaged over a 1-year collection period (n = 10; open bars) compared with people with recently diagnosed clinically isolated syndrome (CIS) (n = 20; shaded bars) and multiple sclerosis (MS) (n = 8, diagonal lines in bars). Individual values are shown and group medians are indicated by the horizontal bar. Statistically significant comparisons in Mann–Whitney tests (p < 0.05) are indicated with as asterisk and very significant comparisons (p < 0.01) are indicated with two asterisks.