Table 2.
Results of regression analyses for serum immunoglobulin levels, adjusting for clinical variables.
| Outcome variable | Independent variable | Unadjusted estimate | 95% Confidence interval |
p-Value | |
| Lower | Upper | ||||
| Total IgG (μg/mL) | MS vs. HC | −1,703.39 | −5,511.1 | 2,104.33 | 0.38 |
| CIS vs. HC | −5,574.52 | −8,966.63 | −2,182.41 | 0.001 | |
| Male vs. female sex | −606.79 | −3,324.34 | 2,110.76 | 0.66 | |
| Age | −57.68 | −202.69 | 87.33 | 0.44 | |
| 25(OH)D | 13.99 | −45.57 | 73.56 | 0.65 | |
| IgA (μg/mL) | MS vs. HC | −1,352.97 | −2,427.85 | −278.09 | 0.014 |
| CIS vs. HC | −887.93 | −1,845.49 | 69.63 | 0.069 | |
| Male vs. female sex | 259.36 | −507.78 | 1,026.50 | 0.51 | |
| Age | −31.69 | −72.63 | 9.24 | 0.13 | |
| 25(OH)D | 6.652 | −10.16 | 23.47 | 0.44 | |
| IgM (μg/mL) | MS vs. HC | 502.84 | 54.34 | 951.34 | 0.028 |
| CIS vs. HC | −209.65 | −609.19 | 189.90 | 0.30 | |
| Male vs. female sex | −494.65 | −814.74 | −147.55 | 0.002 | |
| Age | −2.38 | −19.46 | 14.70 | 0.785 | |
| 25(OH)D | −6.03 | −13.05 | 0.99 | 0.09 | |
| Calculated IgG1 (μg/mL) | MS vs. HC | 1,213.67 | −1,957.62 | 4,384.96 | 0.45 |
| CIS vs. HC | −2,523.73 | −5,348.88 | 301.42 | 0.08 | |
| Male vs. female sex | −591.83 | −2,855.17 | 1,671.51 | 0.61 | |
| Age | −25.95 | −146.72 | 94.82 | 0.67 | |
| 25(OH)D | 4.75 | −44.86 | 54.36 | 0.85 | |
| IgG2 (μg/mL) | MS vs. HC | −3,177.1 | −4,718.33 | −1,635.86 | <0.001 |
| CIS vs. HC | −2,693.94 | −4,066.95 | −1,320.93 | <0.001 | |
| Male vs. female sex | 161.04 | −938.94 | 1,261.01 | 0.77 | |
| Age | −7.50 | −66.19 | 51.20 | 0.8 | |
| 25(OH)D | 4.48 | −19.63 | 28.59 | 0.72 | |
| IgG3 (μg/mL) | MS vs. HC | 544.22 | −7.10 | 1,095.54 | 0.053 |
| CIS vs. HC | −162.53 | −653.67 | 328.62 | 0.52 | |
| Male vs. female sex | −286.54 | −680.01 | 106.94 | 0.15 | |
| Age | −24.77 | −45.76 | −3.77 | 0.02 | |
| 25(OH)D | 4.14 | −4.48 | 12.77 | 0.35 | |
| IgG4 (μg/mL) | MS vs. HC | −284.18 | −635.05 | 66.69 | 0.11 |
| CIS vs. HC | −194.32 | −506.89 | 118.25 | 0.22 | |
| Male vs. female sex | 110.54 | −139.88 | 360.95 | 0.39 | |
| Age | 0.53 | −12.83 | 13.89 | 0.94 | |
| 25(OH)D | 0.62 | −4.87 | 6.11 | 0.83 | |
| Calculated IgG1 (%IgG) | MS vs. HC | 16.25 | 0.84 | 31.66 | 0.03 |
| CIS vs. HC | 3.74 | −9.99 | 17.47 | 0.59 | |
| Male vs. female sex | −2.49 | −13.49 | 8.51 | 0.66 | |
| Age | −0.08 | −0.66 | 0.51 | 0.80 | |
| 25(OH)D | 0.06 | −0.19 | 0.30 | 0.66 | |
| IgG2 (%IgG) | MS vs. HC | −19.9 | −34.33 | −5.47 | 0.007 |
| CIS vs. HC | −6.29 | −19.14 | 6.56 | 0.34 | |
| Male vs. female sex | 1.20 | −9.10 | 11.5 | 0.82 | |
| Age | 0.19 | −0.36 | 0.74 | 0.51 | |
| 25(OH)D | −0.06 | −0.28 | 0.17 | 0.62 | |
| IgG3 (%IgG) | MS vs. HC | 5.00 | 0.69 | 9.31 | 0.02 |
| CIS vs. HC | 2.14 | −1.70 | 5.98 | 0.28 | |
| Male vs. female sex | −0.33 | −3.40 | 2.75 | 0.84 | |
| Age | −0.16 | −0.33 | 0.003 | 0.054 | |
| 25(OH)D | 0.02 | −0.05 | 0.09 | 0.60 | |
| IgG4 (%IgG) | MS vs. HC | −1.36 | −4.36 | 1.64 | 0.38 |
| CIS vs. HC | 0.41 | −2.26 | 3.08 | 0.76 | |
| Male vs. female sex | 1.62 | −0.52 | 3.76 | 0.14 | |
| Age | 0.05 | −0.06 | 0.16 | 0.39 | |
| 25(OH)D | −0.02 | −0.06 | 0.03 | 0.52 | |
| Ratio of IgG1 + IgG3:IgG2 + IgG4 | MS vs. HC | 3.09 | 1.18 | 4.99 | 0.001 |
| CIS vs. HC | 0.60 | −1.10 | 2.30 | 0.49 | |
| Male vs. female sex | −0.45 | −1.81 | 0.91 | 0.52 | |
| Age | −0.01 | −0.09 | 0.06 | 0.74 | |
| 25(OH)D | 0.01 | −0.02 | 0.04 | 0.54 | |
Table shows unadjusted parameter estimates with 95% CIs.
Statistically significant p-values are indicated by bolded font and shading.
p-Values <0.05 indicates a p-value between 0.01 and 0.05.
CI, confidence interval; CIS, clinically isolated syndrome; HC, healthy controls; MS, multiple sclerosis.