Table 2.
Patient and volume characteristics
| HA-WBRT (n = 22) |
Bilateral HA-WBRT (n = 20) |
Unilateral (right) HA-WBRT (n = 2) | |
|---|---|---|---|
| Female | 5 (23%) | 5 (25%) | 0 |
| Male | 17 (77%) | 15 (75%) | 2 (100%) |
| Median age (years) | 65 (27–88) | 65 (27–88) | 69 (61–76) |
| ≤ 65 years | 11 (50%) | 10 (50%) | 1 (50%) |
| > 65 years | 11 (50%) | 10 (50%) | 1 (50%) |
| Number of MBM: | |||
| 1 MBM | 13 (59%) | 12 (60%) | 1 (50%) |
| 2 MBM | 7 (32%) | 6 (30%) | 1 (50%) |
| 3 MBM | 2 (9%) | 2 (10%) | 0 |
| First treatment of MBM: | |||
| Surgery only | 10 (45%) | 9 (45%) | 1 (50%) |
| SRS only | 6 (27%) | 5 (25%) | 1 (50%) |
| Surgery and SRS | 4 (18%) | 4 (20%) | 0 |
| Exclusive SIB concurrent with HA-WBRT | 2 (9%) | 2 (10%) | 0 |
| SRS: | |||
| Median volume (cm3) | 2.07 (0.04–42.6) | 3.01 (0.04–42.6) | 0.96 (0.96) |
| Median dose (Gy) | 20 (14–22) | 20 (14–22) | 16 (16) |
| Volumes (cm3): | |||
| PTV volume | 1434.8 | 1412.7 | 1516.9 |
| Median (Range) | (1177–1640) | (1177–1640) | (1488–1545) |
| R hippocampus volume | 2.27 | 2.27 | 2.54 |
| Median (Range) | (0.9–5.66) | (0.90–5.66) | (1.80–3.27) |
| L hippocampus volume | 2.02 | 1.96 | 2.58 |
| Median (Range) | (1.01–4.45) | (1.01–4.45) | (2.58) |
| Volume of 2 hippocampus | 4.47 | 4.38 | 5.85 |
| Median (Range) | (2.28–9.98) | (2.28–9.98) | (5.85) |
| Sparing volume of 2 hippocampus | 29.52 | 28.53 | 34.77 |
| Median (Range) | (13.4–49.4) | (13.4–49.4) | (34.7) |
| Details of the SIB treatment: | n = 6 | n = 5 | n = 1 |
| 1 MBM | 3 (50%) | 3 (60%) | 0 |
| 2 MBM | 2 (33%) | 1 (20%) | 1 |
| 3 MBM | 1 (17%) | 1 (20%) | 0 |
| Median volume (cm3) | 5.71 (0.54–29.9) | 5.71 (0.74–29.9) | 6.26 (0.54–11.97) |
| Median dose (Gy) | 49.5 (40–50.4) | 47.3 (40–50.4) | 50 (50) |
| Median distance to nearest hippocampus (cm) | 2.8 (0–5.0) | 3.8 (2.0–5.0) | 0.3 (0–0.6) |
Bilateral/Unilateral HA-WBRT: Patients treated with intention to spare bilateral/unilateral hippocampus, HA-WBRT Hippocampal avoidance during whole brain radiotherapy, Hippo Hippocampus, MBM Melanoma brain metastases, PTV Planning target volume, SIB Simultaneous integrated boost, SRS Stereotactic radiosurgery, WBRT Whole brain radiotherapy