Table 1.
Demographic and clinical characteristics of study subjects
| Controls (N = 15) | CD (N = 10) | UC (N = 7) | axSpA (N = 6) | p value | |
|---|---|---|---|---|---|
| Age in years | 48.4 (9.7) | 40.5 (15.2) | 39.2 (12.4) | 34.4 (3.3) | 0.06 |
| Female | 9 (60%) | 7 (70%) | 3 (43%) | 1 (17%) | 0.18 |
| Non-Hispanic white | 15 (100%) | 9 (90%) | 6 (86%) | 6 (100%) | 0.29 |
| Former smoker | 4 (27%) | 5 (50%) | 1 (14%) | 3 (50%) | 0.34 |
| Family history of autoimmunity | 6 (40%) | 3 (30%) | 1 (14%) | 2 (33%) | 0.53 |
| Disease duration in months | – | 127.5 (107.9) | 171.7 (153.9) | 78.5 (58.1) | 0.36 |
| HLA-B27 positivity | 0 | 0 | 1 (14%) | 5 (83%) | 0.0001 a |
| WBC (109 cells/L) | 7.2 (2.2) | 6.6 (2.2) | 5.5 (3.2) | 9.5 (2.3) | 0.04 |
| Absolute lymphocytes (109 cells/L) | 1.9 (0.1) | 1.7 (0.2) | 0.9 (0.1) | 2.6 (0.3) | 0.004 |
| CRP (mg/L) | 2.5 (2.5) | 4.2 (3.0) | 1.7 (1.7) | 5.6 (12.5) | 0.5 |
| TNF inhibitor usage | – | 5 (50%) | 0 (0%) | 5 (83%) | < 0.01 |
| Prednisone usage | – | 2 (20%) | 0 (0%) | 1 (17%) | 0.5 |
| Harvey Bradshaw Index | – | 1.9 (0.526) | – | – | |
| Simple Clinical Colitis Activity Index | – | – | 0.857 (0.553) | – | – |
| Bath AS Disease Activity Index | – | – | – | 3.96 (1.01) | – |
Data are mean (SD) or number (%); p value is based on Fisher’s exact test for categorical variables and on one-way analysis of variance for continuous variables. aBold text indicates significant p-values
HC healthy controls, CD Crohn’s disease, UC ulcerative colitis, axSpA axial spondyloarthritis, CRP C-reactive protein, AS ankylosing spondylitis