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. 2018 Jul 20;16:205. doi: 10.1186/s12967-018-1577-5

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — The distribution of differentially expressed genes in the early and late phase. a The horizontal axis is logFC, and the vertical axis is the P-value after the negative logarithm conversion. The left panel shows the distribution of early-phase lung cancer related genes, and the right panel shows the distribution of late-phase lung cancer related genes. Up- and down-regulated genes are marked in red and green, respectively. b Up/down-regulated genes in the early and late phases are marked with four colour markers. c Each colour block corresponds to the correlation coefficient of two genes: the red represents a positive correlation, and the blue represents a negative correlation. The heatmap matrix from left to right corresponds to the control and the early and late phases