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. 2018 Jul 20;16:201. doi: 10.1186/s12967-018-1580-x

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Resibufogenin RIP3-dependently suppresses heterotropic CRC growth. a HCT116 Cells were pretreated with NSA (1 μM) for 8 h prior to a 24 h treatment with resibufogenin. HCT116 + NSA, HCT116 shControl and HCT116 shRIP3 cells viability was measured by MTT assay (n = 6) b and the proportion of PI-positive cells was analyzed by flow cytometry (n = 3). c Western blotting experiments for RIP3, MLKL, P-MLKL (S358) were performed with the cell lysates obtained after resibufogenin treatment in HCT116 shControl and HCT116 shRIP3 cells. d The picture of colon tumor tissue in mice. e Isolated tumor size and tumor weight from the HCT116 shControl and HCT116 shRIP3 mice heterotropic CRC model

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