Table 3.
Panels of small ncRNA pairs that distinguished between individuals with lung adenocarcinoma, benign lung disease and no lung disease (controls)
| Small ncRNA pairs panels | Training stage | Validation stage | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P-value | RATIO | FC | SEN | SPE | AUC | P-value | RATIO | FC | SEN | SPE | AUC | |
| Panel 1 LAC+Benign vs. Control | ||||||||||||
| miR-22-3p/miR-378a-3p | 1.35E-18 | 1.73 | 3.31 | 0.929 | 0.621 | 0.945 | 2.43E-08 | 1.37 | 2.58 | 0.882 | 0.588 | 0.795 |
| miR-423-5p/miR-378a-3p | 3.80E-08 | 1.61 | 3.05 | 0.953 | 0.552 | 0.849 | 3.92E-10 | 1.87 | 3.65 | 0.868 | 0.608 | 0.840 |
| miR-22-3p/sno-U57 | 1.88E-18 | 2.31 | 4.97 | 0.953 | 0.828 | 0.950 | 1.71E-09 | 2.20 | 4.60 | 0.829 | 0.608 | 0.824 |
| miR-126-5p/sno-U57 | 2.26E-24 | 3.31 | 9.91 | 0.953 | 0.862 | 0.984 | 4.47E-05 | 1.59 | 3.02 | 0.829 | 0.471 | 0.707 |
| miR-152-3p/sno-U57 | 4.02E-21 | 3.37 | 10.32 | 0.941 | 0.828 | 0.970 | 2.48E-05 | 1.64 | 3.11 | 0.829 | 0.529 | 0.718 |
| miR-423-5p/sno-U57 | 2.03E-12 | 2.19 | 4.57 | 0.929 | 0.621 | 0.896 | 1.71E-12 | 2.70 | 6.50 | 0.855 | 0.608 | 0.851 |
| miR-22-3p/sno-SNORD119 | 1.77E-15 | 2.89 | 7.41 | 0.941 | 0.655 | 0.914 | 1.96E-08 | 2.24 | 4.72 | 0.855 | 0.510 | 0.782 |
| Panel 1 LAC vs. Control | ||||||||||||
| miR-22-3p/miR-378a-3p | 1.03E-23 | 2.18 | 4.54 | 0.960 | 0.966 | 0.992 | 2.15E-06 | 1.30 | 2.45 | 0.750 | 0.765 | 0.783 |
| miR-423-5p/miR-378a-3p | 4.20E-12 | 1.79 | 3.45 | 0.920 | 0.690 | 0.883 | 3.65E-09 | 1.94 | 3.84 | 0.727 | 0.706 | 0.845 |
| miR-22-3p/sno-U57 | 1.58E-15 | 2.36 | 5.12 | 0.920 | 0.897 | 0.946 | 1.15E-06 | 1.84 | 3.58 | 0.773 | 0.725 | 0.816 |
| miR-126-5p/sno-U57 | 2.66E-19 | 3.30 | 9.86 | 0.940 | 0.862 | 0.981 | 3.94E-03 | 1.24 | 2.36 | 0.636 | 0.667 | 0.679 |
| miR-152-3p/sno-U57 | 2.83E-16 | 3.19 | 9.11 | 0.860 | 0.897 | 0.964 | 7.17E-04 | 1.40 | 2.63 | 0.636 | 0.686 | 0.708 |
| miR-423-5p/sno-U57 | 5.04E-12 | 2.17 | 4.51 | 0.860 | 0.759 | 0.901 | 1.28E-09 | 2.49 | 5.61 | 0.750 | 0.765 | 0.853 |
| miR-22-3p/sno-SNORD119 | 8.39E-14 | 3.07 | 8.38 | 0.880 | 0.724 | 0.931 | 2.03E-05 | 2.03 | 4.09 | 0.636 | 0.647 | 0.754 |
| Panel 2 (LAC vs. Benign) | ||||||||||||
| miR-374a-5p/miR-126-5p | 6.88E-03 | 0.93 | 1.90 | 0.820 | 0.429 | 0.667 | 2.02E-03 | 0.97 | 1.96 | 0.750 | 0.438 | 0.691 |
| miR-374a-5p/miR-152-3p | 1.39E-03 | 1.35 | 2.55 | 0.800 | 0.514 | 0.696 | 3.06E-02 | 0.70 | 1.63 | 0.750 | 0.313 | 0.625 |
| miR-374a-5p/miR-378a-3p | 9.93E-04 | 1.40 | 2.64 | 0.800 | 0.543 | 0.706 | 3.48E-02 | 0.82 | 1.76 | 0.864 | 0.313 | 0.618 |
| miR-374a-5p/miR-423-5p | 2.46E-02 | 0.96 | 1.94 | 0.820 | 0.314 | 0.622 | 4.26E-02 | 0.64 | 1.56 | 0.841 | 0.375 | 0.624 |
| miR-374a-5p/tRNA-Thr-ACG | 2.77E-02 | 0.94 | 1.91 | 0.760 | 0.229 | 0.680 | 2.09E-02 | 0.92 | 1.90 | 0.750 | 0.313 | 0.663 |
AUC area under receiver operating characteristic curve, FC fold change, SEN sensitivity, SPE specificity. RATIO and FC were calculated using the equations given in the Methods section