Table 2.

Glycogenes upregulated in HeLa shE6/E7 cells

Gene/enzyme	Enzyme function	Gene alteration in cancer and oncogenic associated-effects
ALG14 UDP-N-Acetylglucosaminyltransferase Subunit	Associates with ALG13 and transfers a GlcNAc on GlcNAc-PP-Dol (second step of N-linked glycosylation)	Not reported
FUT4 Fucosyltransferase 4	Catalyzes the transfer of fucose (Fuc) residues from GDP-Fuc to [Fucα1 → 2Galβ1 → 4GlcNAcβ1 → R] in α-1, 3 linkage	mRNA upregulated in acute myeloid leukaemia [54], gastric [30] and colorectal cancers [32]. Protein upregulated in breast cancer was associated with proliferation and metastasis [31]
MAN2A1 Mannosidase Alpha Class 2A Member 1	Hydrolyzes two peripheral mannosyl residues from Manαl--6(Manαl--3) Manαl--6(GlcNAcβ1--2Manα1--3) [Manβ1--4GlcNAcβ1--4GlcNAcβ1]- asparagine structure	MAN2A1– FER tyrosine kinase fusion gene is expressed in liver tumours, oesophageal adenocarcinoma, glioblastoma multiforme, prostate tumours, non-small cell lung tumours, and ovarian tumours [55].
DPY19L1 Dpy19 like 1 (C. elegans)	Participates in the C-mannosylation of tryptophan residues on target proteins.	Not reported
C3orf21 (XXYLT1) Xyloside Xylosyltransferase 1	Elongates the O-linked xylose-glucose disaccharide attached to EGF-like repeats (Notch proteins) by catalyzing the addition of the second xylose	Lower frequency of wild type genotype in the C3orf21 gene rs 2,131,877 locus in lung adenocarcinoma tissues [56]
IDUA Iduronidase, Alpha-L-	Cleaves α-linked iduronic acid residues from the nonreducing end of the glycosaminoglycans (GAGs), heparan sulfate, and dermatan sulfate	Not reported
UGT2B17 UDP Glucuronosyltransferase Family 2 Member B17	Catalyzes the glucuronidation of steroids (detoxification)	mRNA upregulated in endometrial cancer [33]
POFUT1 Protein O-Fucosyltransferase 1	Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine of EGF domains	mRNA upregulated in glioblastomas [26] Protein upregulated in oral squamous cell carcinoma [29]
UGCGL1 UDP-Glucose Glycoprotein Glucosyltransferase 1	Reglucosylates single N-glycans near the misfolded part of the protein	Not reported

Table showing upregulated glycogenes, the names of the coded enzymes, their alteration in different cancer types and their oncogenic-associated-effects