Table 3.

Glycogenes downregulated in HeLa shE6/E7 cells

Gene/enzyme	Enzyme function	Gene alteration in cancer and oncogenic- associated-effects
PIGV Phosphatidylinositol Glycan Anchor Biosynthesis Class V	Transfers the second mannose in the glycosylphosphatidylinositol (GPI) anchor	Not reported
GALNT1 Polypeptide N-Acetylgalactosaminyltransferase 1	Transfers N-acetylgalactosamine (GalNAc) to a serine or threonine residue O-glycosylation	mRNA upregulated in bladder cancer stem cells [57]
C1GALT1C1 C1GALT1 Specific Chaperone 1	Specific chaperone assisting the folding/stability of C1GALT1, for the generation of core 1 O-glycan T antigen	mRNA and protein upregulated in colorectal cancer [27]
FCMD Fukutin	Glycosyltransferase involved in the biosynthesis of α-dystroglycan (α-DG)	Not reported
MANBAL Mannosidase, beta A, lysosomal-like	Mannosidase beta-like	Not reported
B4GALT2 Beta-1,4-Galactosyltransferase 2	Transfers galactose to the terminal N-acetylglucosamine of complex-type N-glycans	Missense mutations in B4GALT2 gene in colon cancer with a predictive deleterious phenotype [58]
UGT8 Ceramide UDP-Galactosyltransferase	Catalyzes the transfer of galactose to ceramide (biosynthesis of GalCer)	mRNA and protein upregulated in breast [28] and increased protein expression in lung cancer [59]

Table showing downregulated glycogenes, the names of the coded enzymes and their alteration in different cancer types