Figure 1.
Ang-(1-7) induces a dose-dependent vasodilatory effect in aorta of both young and elderly male mice. (a) Concentration–response curves to Ang-(1-7) (10−10 to 10−6M) in thoracic aortic rings from male mice. Ang-(1-7) induces a dose-dependent vasodilation in aortic rings from both young (n=9) and old (n=8) male mice. (b) Concentration–response curves to acetylcholine (10−9 to 10−4 M) in thoracic aortic rings from young (n=9) and old (n=8) males. (c) Concentration–response curves to sodium nitroprusside (10−10 to 10−6 M) in thoracic aortic rings from young (n=9) and old (n=8) males. The endothelial function of thoracic aorta was preserved in response to both vasodilatory drugs. ▲: young males; △: old males. ANOVA followed by Newman–Keuls Multiple Comparison post hoc test was performed as statistical analysis. Each point represents the mean ± SEM. *p < 0.05.