Figure 3.

Intrinsic excitability of cells implemented in CNModel. Panels A-E are from the models of Rothman and Manis (2003c). Panel F shows an “Octopus, II-o” cell, which is a variation on the bushy cell, with a modified hyperpolarization activated current, and an elevated low-voltage activated potassium conductance. Simulations in A-F were all run at 22 °C. Panels G-I are simulations based on mouse cochlear nucleus neurons from Xie and Manis (2013). Panels J-L show DCN cell models. The simulation in J is from the model of pyramidal cells in rat (Kanold and Manis, 2001). K and L are ad-hoc representations constrained by current-clamp observations as described in the text. Panels M and N are spiral ganglion cell models, based on the mouse bushy cell model (G), but with the hyperpolarization-activated K current from Liu et al. (2014) for basal-middle (M) SGCs and apical (N) SGCs. Models in G-N were all run at 34 °C. Inset scale bar applies to all voltage traces. Temperature and current ranges are shown beneath the traces. Previously unpublished, ad-hoc models, are shown on a grey background.