Table 2.
Demographic and clinical features of enrollees with vs. without isolated head tremor.
| FD-ET (n = 241) | Co (n = 77) | |||||
|---|---|---|---|---|---|---|
| Demographic or clinical feature | Isolated head tremor present (n = 26) | Isolated head tremor absent (n = 215) | Sig | Isolated head tremor present (n = 2) | Isolated head tremor absent (n = 75) | Sig |
| Current age in years | 60.6 ± 10.3 [62.5] | 56.8 ± 9.8 [56.0] | 0.05a | 52.5 ± 16.3 [52.5] | 57.0 ± 9.4 [57.0] | 0.69a |
| Female gender | 22 (84.6) | 142 (66.0) | 0.055b | 1 (50.0) | 24 (32.0) | 0.55c |
| Education in years | 16.2 ± 1.9 [16.0] | 16.7 ± 2.8 [16.0] | 0.28a | 17.5 ± 2.1 [17.5] | 16.5 ± 3.5 [16.0] | 0.50a |
| White race | 26 (100) | 206 (95.8) | 0.60c | 1 (50.0) | 72 (96.0) | 0.10c |
| Current cigarette smoker | 0 (0.0) | 4 (1.9) | 1.00c | 0 (0.0) | 0 (0.0) | 1.00c |
| Number of prescription medications | 3.2 ± 4.5 [1.5] | 1.9 ± 2.2 [1.0] | 0.47a | 2.0 ± 1.4 [2.0] | 2.6 ± 2.8 [2.0] | 0.99a |
| CIRS score | 5.4 ± 4.4 [4.0] | 4.3 ± 3.3 [4.0] | 0.31a | 1.5 ± 0.7 [1.5] | 4.0 ± 3.6 [3.0] | 0.25a |
| Genetic loadd | 1.3 ± 0.6 [1.0] | 1.4 ± 0.9 [1.0] | 0.85a | 0.0 ± 0.0 [0.0] | 0.0 ± 0.0 [0.0] | 1.0a |
| Total tremor score | 7.6 ± 2.8 [7.0] | 7.4 ± 2.7 [7.0] | 0.87a | 4.75 ± 1.1 [4.75] | 6.5 ± 2.9 [6.0] | 0.42a |
Values are mean ± standard deviation [median] or number (percent). CIRS, Cumulative Illness Rating Scale; Sig, significance.
a
Mann–Whitney test.
b
Chi-square test.
c
Fisher's exact test.
d
The number of reportedly affected first-degree relatives was defined as the genetic load.