Figure 1.

Effect of TLR4 on the expression of P-p38 in the synovial membranes. Immunohistochemical staining for P-p38 in the synovial membranes of (A) the control group, (B) the occlusal interference group, and (C) the TAK-242 group. (D) The mean optical density of each groups. As the results show, in comparison with the control group, the expression of P-p38 was significantly increased in the occlusal interference group. However, this effect could be inhibited significantly after treatment with the TAK-242. Data shows all the values from independent samples of n=6, * P<0.05 vs. control group, ^# P<0.05 vs. occlusal interference group.