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. 2018 Jun 26;24:4405–4412. doi: 10.12659/MSM.908526

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© Med Sci Monit, 2018

This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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Effect of P-p38 on the expression of IL-1β in the synovial membranes. Immunohistochemical staining for IL-1β in the synovial membranes of (A) the control group, (B) the occlusal interference group, and (C) the SB203580 group. (D) The mean optical density of each groups. (E) The relative mRNA expression of IL-1β of each group. As the results show, in comparison with the control group, the expression of IL-1β was significantly increased in the occlusal interference group at both protein and mRNA levels. However, this effect could be inhibited significantly after treatment with the SB203580. Data shows all the values from independent samples of n=6, * P<0.05 vs. control group, ^# P<0.05 vs. occlusal interference group.