Table 3. Alpha diversity and dysbiosis index results for cats that received clindamycin and placebo or synbiotic.
Median (range) results for feces collected at baseline (days 5–7), at the conclusion of antibiotic administration (days 26–28), and after a 603 day washout (days 631–633) from 16 healthy cats, eight per group, + that received 150 mg clindamycin with either a placebo or synbiotic PO once daily for 21 days. + Feces from one cat (synbiotic group) unavailable at the days 631–633 timepoint. Cells that do not share a common superscript letter differed significantly (P < 0.05) based on post-hoc analysis.
| Baseline | Days 26–28 | Days 631–633 | P-value | ||||
|---|---|---|---|---|---|---|---|
| Placebo | Synbiotic | Placebo | Synbiotic | Placebo | Synbiotic | ||
| Shannon index | 3.9a (3.3–5.3) |
4.2a (3.5–4.8) |
2.5b (1.8–3.0) |
2.8b (2.1–3.1) |
4.4a (3.6–5.2) |
4.9a (3.0–5.6) |
<0.001 |
| Goods coverage | 0.9859a (0.9794–0.9919) |
0.9857a (0.9819–0.9920) |
0.9906b (0.9870–0.9942) |
0.9907b (0.9875–0.9927) |
0.9858a (0.9809–0.9909) |
0.9866a (0.9815–0.9894) |
<0.001 |
| Chao1 metric | 2,085a (1,126–3,158) |
1,960a (1,044–2,930) |
1,419b (830–2,026) |
1,408b (1,043–2,062) |
2,119a (1,272–2,945) |
1,976a (1,349–2,622) |
<0.001 |
| Dysbiosis index | −2.9c (−5.5 to −1.6) |
−3.0c (−5.2 to −0.2) |
1.6b (0.4 to 3.3) |
4.7a (1.1 to 5.4) |
−2.6c (−5.1 to −1.0) |
−4.4c (−5.2 to −0.4) |
<0.001 |