Table 3. The ten fragments obtained from fragment screening that showed affinities better than 1 mM: structures, molecular weights, response levels from the initial fragment screening and respective K_D values.

Compound name	Structure	Molecular weight [Da]	SPR response a [%]	K D b [mM]
MB605		140.1	215	0.31 ± 0.04
MB1261		134.1	95	0.35 ± 0.04
MB1318		170.6	61	0.36 ± 0.04
MB1082		146.2	53	0.37 ± 0.04
MB417		180.2	87	0.42 ± 0.04
MB895		157.2	53	0.43 ± 0.05
AT0381		118.1	53	0.74 ± 0.06
CA023		95.1	52	0.77 ± 0.06
MB1284		149.2	90	0.86 ± 0.07
MB1315		162.2	52	0.94 ± 0.09

^aNormalised relative value against NK1.

^bSteady-state binding constant from SPR.