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Model for pRb:CBP:E7 ternary complex formation.4 E7 dimerization through the CR3 domain facilitates recruitment of CBP to Rb. The disordered CR1/CR2 domain of one monomer interacts with the pRb B domain, while the other interact with TAZ2 in a ternary complex that brings the catalytic HAT domain of CBP close to the pRb C domain, enabling acetylation at pRb lysines 873 and 874 and promoting pRb degradation. (Reproduced with permission from ref. 4).
