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. Author manuscript; available in PMC: 2018 Jul 20.
Published in final edited form as: Gastroenterology. 2012 Oct 3;144(1):145–154. doi: 10.1053/j.gastro.2012.09.055

Figure 3. Contributions of 5-HT and CGRP to colonic peristalsis.

Figure 3.

Peristaltic contractions of isolated proximal colon were recorded from C57BL/6 mice. A. Representative recordings of ascending contraction and descending relaxation showing that GR113808 or CGRP8–37 attenuated DCA (100 pM)-stimulated peristalsis. B, C. Mean results of ascending contraction and descending relaxation to graded concentrations of DCA (B) or LCA (C) (1–100 μΜ). GR113808 or CGRP8–37 attenuated DCA- and LCA-stimulated peristalsis, although CGRP8–37 was more effective. *P<0.05, **P<0.005, ***P<0.001 to vehicle.