Table 3.
Brain tissue growth in VPT infants before and after 33–34 weeks’ gestation as a percentage of ICV
| Tissue Growth (% ICV) | ||||
|---|---|---|---|---|
| Tissue Type | Delta | Mean (SD) (n=9) | Mean Difference (95% CI) | P-value |
| Total Tissue | 1 2 |
70.84 (13.62) 79.33 (7.43) |
8.50 (−2.14, 19.13) | .103 |
| CSF | 1 2 |
37.04 (28.56) 20.67 (7.43) |
−16.37 (−37.87, 5.13) | .117 |
| Unmyelinated WM | 1 2 |
30.62 (8.03) 20.60 (4.92) |
−10.02 (−19.00, −1.05) | .033 |
| Myelinated WM | 1 2 |
0.99 (0.32) 1.10 (0.40) |
0.11 (−0.27, 0.49) | .516 |
| Cortical GM | 1 2 |
29.42 (7.31) 47.24 (7.48) |
17.82 (10.39, 25.25) | .001 |
| DNGM | 1 2 |
5.92 (5.23) 4.31 (0.77) |
−1.61 (−5.68, 2.46) | .389 |
| Cerebellum | 1 2 |
5.53 (1.11) 6.08 (0.70) |
0.55 (−0.12, 1.21) | .093 |
Delta 1: ≤33–34 weeks; Delta 2: ≥33–34 weeks
VPT=very preterm; SD=standard deviation; CI=confidence interval; CSF=cerebrospinal fluid; WM=white matter; GM=grey matter; DNGM=deep nuclear grey matter; ICV=intracranial volume