Figure 1.

Low-dose DOX administration does not induce overt morbidity or mortality. (A) Scheme of study design for investigating the effects of low dose DOX treatment. (B) Survival rate (n = 22–23) and (C) weekly body weight change during and after DOX treatment (n = 9). (D) Locomotor activity in the light and dark cycles in control and DOX-treated mice, measured 1 week after the last DOX injection (n = 6). (E) Food consumption during DOX treatment (n = 6). Body composition measured by echo MRI after a 5 weeks of recovery (n = 7): (F) percentage of lean mass and (G) percentage of fat mass. *P < 0.05 vs control. Values are presented as mean ± SEM and analysed by the unpaired Student’s two-tailed t-test.