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. 2018 Apr 6;114(10):1350–1359. doi: 10.1093/cvr/cvy064

Figure 2.

Figure 2

Low-dose DOX regimen causes ‘sub-clinical’ cardiac injury. (A) Heart weight normalized to tibia length (HW/TL) at 1 week after the last DOX injection (n = 5). (B) Gene expression of ANP normalized to beta-actin (n = 3–4). Representative immunoblots (n = 5): (C) p53 normalized to alpha-Tubulin; (D) VEGF normalized to alpha-Tubulin; (E) phospho (Thr202/Try204)-ERK1/2 normalized to total-ERK 1/2; (F) phospho (Thr183/Tyr185)-JNK normalized to total-JNK; and (G) phospho (Thr180/Try182)-p38 normalized to total-p38. *P < 0.05 vs. control. P-indicates phospho-. Values are presented as mean ± SEM and analysed by the unpaired Student’s two-tailed t-test.