Table 1.
Cardiac function and morphology in mice at 5 weeks after the last DOX injection
| Control | DOX | |
|---|---|---|
| HR (bpm) | 417 ± 9 | 432 ± 28 |
| Cardiac function | ||
| EF (%) | 61.0 ± 4.4 | 60.1 ± 4.1 |
| Mitral E/A ratio | 1.60 ± 0.08 | 1.55 ± 0.19 |
| SV (µL) | 49.7 ± 6.4 | 43.7 ± 9.6 |
| CO (mL/min) | 22.7 ± 3.0 | 21.7 ± 5.0 |
| Morphology | ||
| LVPW-diastole (mm) | 0.74 ± 0.03 | 0.70 ± 0.07 |
| LVPW-sytole (mm) | 1.11 ± 0.13 | 0.91 ± 0.06 |
| LVID-diastole (mm) | 4.27 ± 0.35 | 4.03 ± 0.46 |
| LVID-systole (mm) | 2.92 ± 0.43 | 2.81 ± 0.43 |
| LVEDV (µL) | 82.3 ± 15.7 | 72.2 ± 19.5 |
| LVESV (µL) | 33.6 ± 12.0 | 30.8 ± 11.3 |
| LV mass (mg) | 101.0 ± 9.1 | 88.0 ± 16.0 |
Values are mean ± SEM (n = 3–4). HR, heart rate; EF, ejection fraction; SV, stroke volume; CO, cardiac output; LVID, LV internal diameter; LVEDV, LV end-diastolic volume; LVESV, LV end-systolic volume.