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. 2018 May 23;114(10):1287–1303. doi: 10.1093/cvr/cvy122

Figure 5.

Figure 5

Three examples of MOGE(S) application in ACM (A), familial DCM (B), and sporadic DCM phenotype caused by chronic myocarditis (C). The left column shows the pedigrees of three families. The right column shows how family members are described by the MOGE(S) system including the imaging view of the proband (B) and the pathology features in endomyocardial biopsy of the index patient of family C (C). For arrhythmogenic cardiomyopathy, descriptors of the phenotype can detail the combination of major and minor criteria or define family members as diagnosed with definite, possible, and borderline cardiomyopathy according to the 2010 Task Force. For dilated cardiomyopathy, the age dependency of the phenotype explains the absence of clinical signs in the two children (IV:1 and IV:5) of the fourth generation. The p.(Arg190Trp) in LMNA is a recurrent, highly penetrant, malignant, and validated mutation (https://www.ncbi.nlm.nih.gov/clinvar/variation/66908/).