Table III.

Internal loop disorder observed in wild-type GTB and Arg188 and Asp302 mutant structures. All residues in these internal loops lie in conformations corresponding to the “open” state described by Alfaro et al. (2008)

Enzyme	Internal loop
	175	180	185	190
GTBa	VGayk	rWQDV	SMRRM	EMISD
GTA/D302C	VRayk	rwqDV	SMRRM	EMISD
GTB/D302A	VGayk	rwqdv	smrrm	emisd
GTB/D302C	Vgayk	rwqdv	smrrm	emiSD
GTB/D302L	Vgayk	rwqdV	SMRRM	EMISD
GTB/R188K	VGayk	rwqdV	SMRKM	EMISD

^aPDB code: 2RIT (Alfaro et al. 2008).

One-letter amino acid codes with upper case black letters correspond to unambiguous electron density for main chain and side chain atoms, blue corresponds to unambiguous electron density for main chain atoms only; red letters correspond to weak or ambiguous electron density for main chain and side chain atoms. Residues with one-letter amino acid codes in lower case have not been included in the refined models.