. 2018 Jun 20;28(8):624–636. doi: 10.1093/glycob/cwy051

Table VI.

Representative structures deposited in the Protein Data Bank of retaining and inverting GT-A fold GTs with salt bridge residues corresponding to GTA/GTB (family GT-6) residues Arg188, Asp211 and Asp302

Reaction stereochemistry	Family	Example enzyme	Donor analog	Acceptor analog	PDB	Arg188 equivalent	Asp211 equivalent	Asp302 equivalent
Retaining	GT-8	α-1,4-galactosyltransferase, LgtC^a	UDP 2-deoxy-2-fluoro-galactose	4′deoxylactose	1GA8	Arg86	Asp103	Asp188
	GT-15	α1,2-mannosyltransferase, Kre2p/Mnt1p^b	GDP	O1-methyl-mannose	1S4P	Arg245*	Glu247	Asp361
	GT-27	polypeptide GalNAc-transferase 2, GalNAc-T2^c	UDP-N-acetylgalactosamine	EA2 peptide	4D0T	Arg208	Asp224	Glu334
	GT-55	mannosyl-3-phosphoglycerate synthase^d	GDP-α-D-mannose	-	2ZU8	Lys145	Asp168	Glu271
	GT-64	α-1,4-N-acetylhexosaminyltransferase, EXTL2^e	UDP	[glucuronic acid]β1–3[galactose]β1-O-naphthalenemethanol	1ON8	Arg135	Asp151	Asp245
	GT-78	mannosylglycerate synthase, MGS^f	GDP	Malonate ion	2Y4L	Lys76	Asp100	Asp192
	GT-81	glucosyl-3-phosphoglycerate synthase^g	UDP	3-phosphoglyceric acid	4DEC	Lys114	Asp134	Glu232
Inverting	GT-2	Teichoic acid β-glycosyltransferase^h	UDP-N-acetylgalactosamine	-	5TZJ	Arg75	Asp91	Glu177
	GT-7	β1–4-galactosyltransferase-I, β4Gal-T1ⁱ	UDP	[N-acetylglucosamine] β1–6[galactose]β1-4[glucose]	4EEA	Arg224	Asp248	Glu313
	GT-13	O-linked mannose β1,2-N-acetylglucosaminyltransferase 1, POMGnT1^j	UDP	O-mannosylated peptide	5GGI	Tyr372	Glu393	Trp475
	GT-43	Glucuronyltransferase, GlcAT-P^k	UDP	N-acetyllactosamine	1V84	Arg170	Asp195	Gln283

^aPersson et al. (2001b).

^bLobsanov et al. (2004).

^cLira-Navarrete et al. (2014).

^dKawamura et al. to be published.

^ePedersen et al. (2003).

^fNielsen et al. (2011).

^gUrresti et al. (2012).

^hSobhanifar et al. (2016).

ⁱRamakrishnan et al. (2012).

^jKuwabara et al. (2016).

^kKakuda et al. (2004).

*Unlike GTA/GTB Arg188 and the corresponding residues of the other GT-A fold GTs, Arg160 in this family 15 enzyme does not reside within an ordered alpha helix, though it appears to play the same or similar role in salt bridge formation.