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. 2018 Jul 18;4(2):vey019. doi: 10.1093/ve/vey019

Table 2.

VP2 amino acid signatures putatively involved in IPNV virulence.

	Amino acid signatures
Site	Highly virulent	Moderately virulent	Avirulent	Italian IPNV (No.)
199	T^a	I^a	I^a	T (1/75), I (74/75)
217	T^a–d	A^b, P^a^,d	P^a,^c	P (75/75)
221	A^c^,d, T^a	A^a^{, d}	T^c^{, d} A^a	T (75/75)
247	T^a	A^a	A^a	A (75/75)
286	K^b	A^b	–	G (28/75), R (47/75)
288	V^a	A^a	V^a	V (75/75)
500	Y^a	H^a	H^a	H (3/75), Y (72/75)

The specific amino acid residue and the associated phenotype are shown for each site. The number of Italian IPNV strains harboring specific amino acid signatures are reported in the last column.

^a

Shivappa et al. (2004).

^b

Bruslind and Reno (2000).

^c

Santi, Vakharia, and Evensen (2004).

^d

Song et al. (2005).