Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2017 Sep 23;110(3):265–272. doi: 10.1093/jnci/djx176

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author 2017. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com.

PMC Copyright notice

Figure 3. — Ov.RS2 and BRCA1 loss of function in high-grade serous ovarian cancer (HGSOC). A) Comparison between Ov.RS2 and the previously identified Br.RS3 rearrangement signature (8). The contribution of clustered rearrangements was omitted for clarity. B) Ov.RS2 rearrangement signature contribution in HGSOC tumors with germline or somatic BRCA1 mutations compared with tumors with no homologous recombination pathway lesion. C) Ov.RS2 rearrangement signature contribution in HGSOC tumors with germline BRCA1 mutations compared with tumors with somatic BRCA1 mutations and non-BRCA1 mutated tumors. D) Ov.RS2-CN rearrangement signature similarity in HGSOC tumors with germline or somatic BRCA1 mutations compared with non-BRCA1 mutated tumors in The Cancer Genome Atlas cohort. All comparisons were performed using a two-sided Wilcoxon rank-sum test. AOCS = Australian Ovarian Cancer Study; LOF = loss of function; TCGA = The Cancer Genome Atlas; Tr = inter-chromosomal translocation.