Table 2.
Multivariable Cox regression model adjusted for all covariates estimating overall survival among patients from the TCGA cohort, stratified by Ov.RS3-CN similarity relative to the median (n = 490)
| Variable | HR (95% CI) | P* |
|---|---|---|
| Age at diagnosis, y | ||
| <65 | 1.00 (reference) | |
| ≥65 | 1.54 (1.20 to 2.00) | <.001 |
| FIGO stage at diagnosis | ||
| III | 1.00 (reference) | |
| IV | 1.40 (1.01 to 1.93) | .04 |
| Ov.RS3-CN similarity | ||
| Below median | 1.00 (reference) | |
| Above median | 1.59 (1.24 to 2.03) | <.001 |
| Primary chemotherapy response | ||
| Refractory or resistant | 1.00 (reference) | |
| Sensitive | 0.39 (0.28 to 0.54) | <.001 |
| Unknown | 0.47 (0.32 to 0.68) | <.001 |
| Primary tumor-reductive surgery result | ||
| No residual disease | 1.00 (reference) | |
| 1–10 mm residual disease | 1.73 (1.14 to 2.61) | .01 |
| >10 mm residual disease | 1.69 (1.10 to 2.62) | .02 |
| Unknown | 0.72 (0.40 to 1.31) | .28 |
*
Multivariable analyses were performed using the Cox model for overall survival, and the statistical test was two-sided. CI = confidence interval; FIGO = Fédération Internationale de Gynécologie et d'Obstétrique; HR = hazard ratio; TCGA = The Cancer Genome Atlas.