Figure 1.

TERT copy gain in 573 AM specimens.

Notes: (A) A DNA copy number of >2 copies was determined as gene copy gain, and TERT copy gain was observed in 44.9% (257/573) of the AM specimens (above the X-axis). (B) The scatter plot showed different degrees of copy gain of TERT as follows: no copy gain is defined as a copy number of 2 or less, while a copy gain is defined as a copy number >2. In these amplified populations, we further defined <2 copy number and <4 as median copy number gain. A copy number <4 is defined as high copy number gain.

Abbreviation: AM, acral melanoma.