Table 3.

Cox regression analysis of the correlation between TERT copy number and clinicopathologic factors with RFS

Factors	Group	HR	95% CI	P-valuea
Univariate analysis
Sex	Female vs male	0.930	0.671–1.290	0.660
Age	≥65 vs 65	0.687	0.462–1.023	0.087
TNM stage	III and IV vs I and II	2.893	2.031–4.121	<0.001
Ulceration	Ulceration vs nonulceration	1.092	0.776–1.536	0.612
Thickness	≥4 vs 4	1.142	0.812–1.598	0.422
TERT copy gain	Gain vs no gain	1.465	1.042–2.059	0.018
BRAF mutation	Mut vs WT	1.027	0.631–1.672	0.912
NRAS mutation	Mut vs WT	1.186	0.721–1.95	0.502
CKIT mutation	Mut vs WT	1.239	0.703–2.183	0.409
Multivariate analysis
TERT copy gain	Gain vs no gain	1.496	1.069–2.094	0.019
TNM stage	III and IV vs I and II	2.922	2.095–4.077	<0.001

Note:

^aThe P-value was analyzed by the χ² tests.

Abbreviations: HR, hazard ratio; Mut, mutation; RFS, relapse-free survival; TNM, tumor-node-metastasis; WT, wild type.