Table 2.
Summary of gene regions significantly associated with more than one cancer.
| Candidate genes | Select. region | Nr. of SNPs/region | Nr. of associated SNPsa | Associated cancers | Strongest association | Previously in GWAS associated cancersb |
|---|---|---|---|---|---|---|
| RUVBL1 | 3: 127733628-127922757 | 346 | 27 (1) | Endometrioid ovarian cancer, overall prostate cancer, colorectal cancer | Endometrioid ovarian cancer, Overall prostate cancer: rs144609957 - OR: 1.13; 95% CI: 1.08–1.19; p: 3.44*10−7 | Prostate cancer |
| TET2 | 4: 106017842-106250960 | 573 | 9 (3) | Overall prostate cancer, overall ovarian cancer, endometrioid ovarian cancer, overall breast cancer, clear cell ovarian cancer, colorectal cancer | Overall prostate cancer, endometrioid ovarian cancer: rs6839705 - OR: 1.11; 95% CI: 1.07–1.16; p: 3.32*10−7 | Prostate cancer, breast cancer |
| L3MBTL3 | 6: 130289728-130512594 | 590 | 11 (2) | Colorectal cancer, overall breast cancer, ER-neg breast cancer, clear cell ovarian cancer, overall prostate cancer, aggressive prostate cancer | Colorectal cancer, overall breast cancer, ESR1 (ER)-negative breast cancer, clear cell ovarian cancer, overall prostate cancer, aggressive prostate cancer: rs9388766 - OR 1.06; 95% CI: 1.03–1.08; p: 1.07*10−6 | None |
| HDAC9 | 7: 18076572-18758466 | 1307 | 1 (1) | Lung adenocarcinoma, squamous cell lung cancer, colorectal cancer, clear cell ovarian cancer | Lung adenocarcinoma, squamous cell lung cancer, colorectal cancer, clear cell ovarian cancer: rs190505819 - OR: 1.88; 95% CI: 1.44–2.45; p: 2.95*10−6 | None |
| BRCA2 | 13: 32839617-33023809 | 196 | 1 (1) | Overall lung cancer, squamous cell lung cancer, colorectal cancer | Overall lung cancer, squamous cell lung cancer, colorectal cancer: rs56404467 - OR: 1.30; 95% CI: 1.15–1.48; p: 3.26*10−5 | Breast cancer, lung cancer |
| MORF4L1 | 15: 79115123-79240081 | 327 | 15 (2) | Overall lung cancer, lung adenocarcinoma, squamous cell lung cancer, clear cell ovarian cancer | Overall lung cancer, lung adenocarcinoma, clear cell ovarian cancer: rs7179953 - OR: 0.93; 95% CI: 0.91–0.96; p: 5.34*10−7 | Lung cancer |
| BABAM1 | 19: 17328232-17443811 | 404 | 33 (5) | Squamous cell lung cancer, ER-neg breast cancer, serous ovarian cancer, overall breast cancer, overall ovarian cancer, overall prostate cancer, | Squamous cell lung cancer, ESR1 (ER)-negative breast cancer, serous ovarian cancer: rs4808076 - OR: 1.14; 95% CI: 1.10–1.19; p: 1.77*10−10 | Breast cancer, ovarian cancer |
| DPF1 | 19: 38651649-38770317 | 284 | 2 (1) | Overall prostate cancer, ER-neg breast cancer, endometrioid ovarian cancer, aggressive prostate cancer | Overall prostate cancer, ER-neg breast cancer, endometrioid ovarian cancer, aggressive prostate cancer: rs12611084 - OR 0.93; 95% CI: 0.91–0.96; p: 8.40*10−8 | Prostate cancer |
Nr=Number; SNP=Single nucleotide polymorphism; GWAS=Genome-wide association study; OR=Odds ratio; CI=Confidence interval; ER=Estrogen receptor
a
Independent associations
b
associated with breast, colorectal, lung, ovarian or prostate cancer