Table 2.
Effect of intercalated cell Nedd4–2 gene ablation on serum electrolytes, arterial blood gases, and serum aldosterone
| Cre (−), Floxed Nedd4–2, Wild Type | Cre (+), IC Nedd4–2 Null | P Value | |
|---|---|---|---|
| Na+, mEq/L | 144±1 (n=4) | 144±1 (n=4) | NS |
| K+, mEq/L | 3.3±0.2 (n=4) | 3.0±0.2 (n=4) | NS |
| Cl−, mEq/L | 115±1 (n=4) | 115±1 (n=4) | NS |
| HCO3−, mEq/L | 20±1 (n=4) | 21±1 (n=4) | NS |
| Aldosterone, nM | 2.3±0.5 (n=12) | 1.6±0.4 (n=14) | NS |
| Arterial pH | 7.5±0.02 (n=4) | 7.47±0.01 (n=4) | NS |
| pCO2 | 25.2±1 | 27.7±1 | NS |
| cHCO3− | 19.4±0.5 | 19.9±0.8 | NS |
Each n represents values from separate mice. Mice consumed the NaCl-rich diet (1.4 mEq/d NaCl) for 7 d before being euthanized. IC, intercalated cell; Na+, sodium; NS, not significant; K+, potassium; Cl−, chloride; pCO2, partial pressure of CO2; cHCO3−, calculated HCO3− concentration.