Table 2.
Risk factors associated with graft loss in univariate analyses
| Univariate Analysis Parameters | HR | 95% CI | P Value |
|---|---|---|---|
| Baseline recipient characteristics | |||
| Age per 1-yr increment | 0.99 | 0.98 to 1.01 | 0.49 |
| Sex | |||
| Women | 1 | — | |
| Men | 1.15 | 0.71 to 1.87 | 0.57 |
| Baseline donor characteristics | |||
| Age per 1-yr increment | 1.00 | 0.99 to 1.02 | 0.41 |
| Sex | |||
| Women | 1 | — | |
| Men | 1.05 | 0.67 to 1.70 | 0.83 |
| Donor HTA | |||
| No | 1 | — | |
| Yes | 1.47 | 0.90 to 2.41 | 0.13 |
| Deceased donor | |||
| No | 1 | — | |
| Yes | 1.37 | 0.72 to 2.61 | 0.34 |
| Extended criteria donor | |||
| No | 1 | — | |
| Yes | 1.69 | 1.06 to 2.71 | 0.03 |
| Baseline transplant characteristics | |||
| Prior kidney transplant | |||
| No | 1 | — | |
| Yes | 2.14 | 1.31 to 3.50 | 0.002 |
| Cold ischemia time, h | |||
| <12 | 1 | — | |
| 12–24 | 1.58 | 0.83 to 3.01 | |
| ≥24 | 1.25 | 0.60 to 2.59 | 0.35 |
| Baseline immunologic characteristics | |||
| No. of HLA-A/-B/-DR mismatches | 0.91 | 0.78 to 1.08 | 0.27 |
| Pre- and/or post-transplant anti-HLA DSA | |||
| DSA | |||
| No | 1 | — | |
| MFI | |||
| <6000 | 1.57 | 0.87 to 2.83 | |
| ≥6000 | 3.78 | 1.89 to 7.53 | <0.001 |
| Immunologic characteristics at biopsy | |||
| >50% Increase in reactivity to MDA in post- compared with pretransplant (Nabs+) | |||
| No | 1 | — | |
| Yes | 2.68 | 1.49 to 4.82 | 0.001 |
| Function at biopsy | |||
| eGFR, ml/min per 1.73 m2 | 0.96 | 0.94 to 0.97 | <0.001 |
| Proteinuria, log transformation | 1.94 | 1.56 to 2.41 | <0.001 |
| Histology at biopsy | |||
| Glomerular and peritubular inflammation | |||
| Low score: 0 | 1 | — | |
| Transplant glomerulopathy | |||
| High score: ≥1 | 2.13 | 1.31 to 3.47 | 0.002 |
| Interstitial fibrosis and tubular atrophy | |||
| Low score: 0 | 1 | — | |
| High score: ≥2 | 1.13 | 0.76 to 2.16 | 0.36 |
| C4d graft deposition | |||
| Low score: 0 | 1 | — | |
| High score: ≥1 | 2.48 | 1.37 to 4.47 | 0.003 |
| Interstitial inflammation and tubulitis | |||
| Low score: 0 | 1 | — | |
| High score: ≥2 | 2.01 | 1.15 to 3.52 | 0.02 |
| Arteriosclerosis | |||
| 0–1 | 1 | — | |
| ≥2 | 1.21 | 0.74 to 1.97 | 0.45 |
| Arteriolar hyalinosis | |||
| 0–1 | 1 | — | |
| ≥2 | 0.96 | 0.50 to 1.83 | 0.90 |
HR, hazard ratio; 95% CI, 95% confidence interval; —, not applicable; HTA, hypertension; DSA, donor-specific antibody; MFI, mean fluorescence intensity; MDA, malondialdehyde; Nabs, natural antibodies.