Skip to main content
. 2018 Mar 30;29(6):1761–1770. doi: 10.1681/ASN.2017111157

Table 2.

Risk factors associated with graft loss in univariate analyses

Univariate Analysis Parameters HR 95% CI P Value
Baseline recipient characteristics
 Age per 1-yr increment 0.99 0.98 to 1.01 0.49
 Sex
  Women 1
  Men 1.15 0.71 to 1.87 0.57
Baseline donor characteristics
 Age per 1-yr increment 1.00 0.99 to 1.02 0.41
 Sex
  Women 1
  Men 1.05 0.67 to 1.70 0.83
 Donor HTA
  No 1
  Yes 1.47 0.90 to 2.41 0.13
 Deceased donor
  No 1
  Yes 1.37 0.72 to 2.61 0.34
 Extended criteria donor
  No 1
  Yes 1.69 1.06 to 2.71 0.03
Baseline transplant characteristics
 Prior kidney transplant
  No 1
  Yes 2.14 1.31 to 3.50 0.002
 Cold ischemia time, h
  <12 1
  12–24 1.58 0.83 to 3.01
  ≥24 1.25 0.60 to 2.59 0.35
Baseline immunologic characteristics
 No. of HLA-A/-B/-DR mismatches 0.91 0.78 to 1.08 0.27
Pre- and/or post-transplant anti-HLA DSA
 DSA
  No 1
 MFI
  <6000 1.57 0.87 to 2.83
  ≥6000 3.78 1.89 to 7.53 <0.001
Immunologic characteristics at biopsy
 >50% Increase in reactivity to MDA in post- compared with pretransplant (Nabs+)
  No 1
  Yes 2.68 1.49 to 4.82 0.001
Function at biopsy
 eGFR, ml/min per 1.73 m2 0.96 0.94 to 0.97 <0.001
 Proteinuria, log transformation 1.94 1.56 to 2.41 <0.001
Histology at biopsy
 Glomerular and peritubular inflammation
  Low score: 0 1
 Transplant glomerulopathy
  High score: ≥1 2.13 1.31 to 3.47 0.002
 Interstitial fibrosis and tubular atrophy
  Low score: 0 1
  High score: ≥2 1.13 0.76 to 2.16 0.36
 C4d graft deposition
  Low score: 0 1
  High score: ≥1 2.48 1.37 to 4.47 0.003
 Interstitial inflammation and tubulitis
  Low score: 0 1
  High score: ≥2 2.01 1.15 to 3.52 0.02
 Arteriosclerosis
  0–1 1
  ≥2 1.21 0.74 to 1.97 0.45
 Arteriolar hyalinosis
  0–1 1
  ≥2 0.96 0.50 to 1.83 0.90

HR, hazard ratio; 95% CI, 95% confidence interval; —, not applicable; HTA, hypertension; DSA, donor-specific antibody; MFI, mean fluorescence intensity; MDA, malondialdehyde; Nabs, natural antibodies.