Table 3.
Risk factors associated with graft loss in multivariable analyses
| Multivariable Analysis Parameters | HR | 95% CI | P Value |
|---|---|---|---|
| eGFR, ml/min per 1.73m2 | 0.97 | 0.96 to 0.99 | <0.001 |
| Proteinuria, g/g creatinine, log | 1.70 | 1.35 to 2.36 | <0.001 |
| >50% Increase in reactivity to MDA in post- compared with pretransplant (Nabs+) | |||
| No | 1 | — | |
| Yes | 2.07 | 1.03 to 4.17 | 0.04 |
| Pre- and/or post-transplant anti-HLA DSA | |||
| No | 1 | — | |
| MFI | |||
| <6000 | 1.12 | 0.59 to 2.12 | |
| ≥6000 | 2.61 | 1.25 to 5.45 | 0.03 |
HR, hazard ratio; 95% CI, 95% confidence interval; MDA, malondialdehyde; Nabs, natural antibodies; —, not applicable; DSA, donor-specific antibody; MFI, mean fluorescence intensity.