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. 2018 Jun 5;67(8):1589–1603. doi: 10.2337/db17-1089

Figure 4.

Figure 4

Impaired BAFF- and APRIL-induced ERK/STAT1 signaling is responsible for the M2 polarization of TACI-deficient Mϕs. A: AT Mϕs from TACI KO or WT HFD mice were stimulated with APRIL plus BAFF for 24 h. Total and phosphorylated ERK1/2 and STAT1 were detected by Western blot analysis. One out of three experiments with similar results is shown. B: Peritoneal Mϕs from wild-type (WT) mice were stimulated with APRIL plus BAFF for 24 h after transfection with control or STAT1 siRNA. Total and phosphorylated forms of STAT1 and ERK1/2 were detected by Western blot analysis. One out of three experiments with similar results is shown. C: The expression of M1-associated genes in these cells was analyzed by real-time PCR. Data presented are the mean ± SD of three experiments. ns, not significant. *P < 0.05, **P < 0.01.