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Summary of APC biological processes affected in T1D with examples. Processes shown are from multiple APCs (DCs, MΦs, B cells, mTECs, stromal cells) and may not all be found in a given type of APC. (+) and (-) denote immunogenic and tolerogenic signals, respectively. Ag, antigen; DRiP, defective ribosomal product; FcR, Fc receptors; HIP, hybrid insulin peptide; VDR, vitamin D receptor.
