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Summary of ASIT approaches and associated therapies for T1D. (+) and (-) denote immunogenic and tolerogenic signals, respectively. Not shown: Exogenous antigens/peptides may be formulated for codelivery with small drugs or other immunomodulators or conjugated with molecules other than the antibody for specific cell targeting. Ag, antigen; Dexa, dexamethasone; ODNs, oligodeoxynucleotides; Rapa, rapamycin; VDR, vitamin D receptor.
