Table 4.
Significance of associations between HbA1c known genetic determinants and fructosamine and percent glycated albumin in ARIC
| SNP | Chr:position | Closest gene | A1/A2 | Whites |
Blacks |
||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| A1 freq | P value fructosamine | P value glycated albumin | P value HbA1c | A1 freq | P value fructosamine | P value glycated albumin | P value HbA1c | ||||
| rs1046896 |
17:80685533 |
FN3KRP |
T/C |
0.31 |
0.034 |
0.048 |
0.052 |
0.24 |
0.661 |
0.455 |
0.585 |
| rs10774625 |
12:111910219 |
ATXN2 |
G/A |
0.48 |
0.571 |
0.032 |
0.008 |
0.09 |
0.221 |
0.142 |
0.503 |
| rs10823343 |
10:71091013 |
HK1 |
G/A |
0.26 |
0.452 |
0.065 |
1.1E-06 |
0.45 |
0.808 |
0.529 |
0.899 |
| rs10830963 |
11:92708710 |
MTNR1B |
G/C |
0.28 |
0.001 |
0.003 |
0.006 |
0.07 |
0.134 |
0.035 |
0.222 |
| rs11248914 |
16:293562 |
ITFG3 |
C/T |
0.35 |
0.011 |
0.229 |
0.055 |
0.36 |
0.067 |
0.354 |
0.485 |
| rs11558471 |
8:118185733 |
SLC30A8 |
G/A |
0.32 |
0.005 |
8.2E-05 |
0.010 |
0.09 |
0.309 |
0.176 |
0.989 |
| rs11603334 |
11:72432985 |
ARAP1 |
A/G |
0.16 |
0.005 |
0.078 |
0.228 |
0.06 |
0.788 |
0.950 |
0.734 |
| rs11708067 |
3:123065778 |
ADCY5 |
G/A |
0.23 |
0.070 |
0.001 |
0.034 |
0.16 |
0.002 |
0.003 |
0.074 |
| rs11954649 |
5:157055491 |
SOX30 |
G/C |
0.00 |
NA |
NA |
NA |
0.05 |
0.812 |
0.220 |
0.184 |
| rs11964178 |
6:109562035 |
C6orf183 |
G/A |
0.43 |
0.861 |
0.844 |
0.702 |
0.36 |
0.180 |
0.748 |
0.475 |
| rs12621844 |
2:48414735 |
FOXN2 |
C/T |
0.39 |
0.732 |
0.294 |
0.358 |
0.84 |
0.829 |
0.853 |
0.666 |
| rs12819124 |
12:48409054 |
RP1 |
A/C |
0.47 |
0.765 |
0.930 |
0.001 |
0.21 |
0.500 |
0.826 |
0.146 |
| rs13134327 |
4:144659795 |
FREM3 |
A/G |
0.32 |
0.800 |
0.662 |
0.031 |
0.30 |
0.220 |
0.854 |
0.772 |
| rs1402837 |
2:169757354 |
G6PC2 |
T/C |
0.22 |
0.016 |
9.3E-05 |
2.7E-07 |
0.31 |
0.471 |
0.728 |
0.656 |
| rs1558902 |
16:53803574 |
FTO |
A/T |
0.41 |
0.545 |
0.017 |
0.131 |
0.11 |
0.065 |
0.176 |
0.514 |
| rs17509001 |
2:24021231 |
ATAD2B |
C/T |
0.14 |
0.309 |
0.152 |
0.027 |
0.09 |
0.604 |
0.524 |
0.802 |
| rs17533903 |
19:17256523 |
MYO9B |
A/G |
0.21 |
0.577 |
0.167 |
5.0E-04 |
0.24 |
0.403 |
0.232 |
0.689 |
| rs17747324 |
10:114752503 |
TCF7L2 |
C/T |
0.23 |
1.7E-04 |
3.2E-05 |
1.8E-04 |
0.07 |
0.396 |
0.755 |
0.890 |
| rs1800562 |
6:26093141 |
HFE |
A/G |
0.06 |
0.337 |
0.128 |
0.001 |
0.01 |
0.846 |
0.670 |
0.146 |
| rs198846 |
6:26107463 |
HFE |
A/G |
0.16 |
0.390 |
0.198 |
0.123 |
0.88 |
0.533 |
0.270 |
0.260 |
| rs2110073 |
12:7075882 |
PHB2 |
T/C |
0.10 |
0.321 |
0.938 |
0.002 |
0.42 |
0.177 |
0.349 |
0.160 |
| rs2383208 |
9:22132076 |
MTAP |
G/A |
0.18 |
0.008 |
0.019 |
0.007 |
0.19 |
0.293 |
0.763 |
0.596 |
| rs2408955 |
12:48499131 |
SENP1 |
G/T |
0.48 |
0.567 |
0.879 |
0.002 |
0.63 |
0.813 |
0.824 |
0.632 |
| rs267738 |
1:150940625 |
CERS2 |
G/T |
0.21 |
0.444 |
0.434 |
0.511 |
0.04 |
0.853 |
0.745 |
0.297 |
| rs2779116 |
1:158585415 |
SPTA1 |
T/C |
0.27 |
0.714 |
0.792 |
9.9E-06 |
0.22 |
0.111 |
0.167 |
0.961 |
| rs282587 |
13:113351662 |
ATP11A |
G/A |
0.12 |
0.586 |
0.248 |
1.0E-04 |
0.69 |
0.050 |
0.142 |
0.246 |
| rs3824065 |
7:44247258 |
GCK |
T/C |
0.42 |
3.3E-04 |
0.002 |
0.125 |
0.24 |
0.086 |
0.134 |
0.910 |
| rs4607517 |
7:44235668 |
GCK |
A/G |
0.17 |
2.0E-04 |
0.003 |
5.7E-05 |
0.11 |
0.088 |
0.097 |
0.244 |
| rs4737009 |
8:41630405 |
ANK1 |
A/G |
0.24 |
0.126 |
0.515 |
0.018 |
0.46 |
0.274 |
0.461 |
0.361 |
| rs4745982 |
10:71089843 |
HK1 |
G/T |
0.07 |
0.190 |
0.263 |
5.8E-06 |
0.10 |
0.889 |
0.921 |
0.602 |
| rs4820268 |
22:37469591 |
TMPRSS6 |
G/A |
0.46 |
0.264 |
0.350 |
0.010 |
0.72 |
0.073 |
0.029 |
0.181 |
| rs560887 |
2:169763148 |
G6PC2 |
T/C |
0.30 |
0.080 |
0.003 |
0.003 |
0.95 |
0.811 |
0.583 |
0.861 |
| rs579459 |
9:136154168 |
ABO |
C/T |
0.23 |
0.268 |
0.340 |
0.001 |
0.13 |
0.210 |
0.487 |
0.600 |
| rs592423 |
6:139840693 |
CITED2 |
A/C |
0.46 |
0.514 |
0.535 |
0.063 |
0.61 |
0.323 |
0.605 |
0.333 |
| rs6474359 |
8:41549194 |
ANK1 |
C/T |
0.03 |
0.979 |
0.486 |
4.3E-04 |
0.27 |
0.077 |
0.047 |
0.879 |
| rs6980507 |
8:42383084 |
SLC20A2 |
A/G |
0.39 |
0.256 |
0.873 |
0.015 |
0.48 |
0.514 |
0.557 |
0.663 |
| rs7040409 |
9:91503236 |
C9orf47 |
G/C |
0.07 |
0.499 |
0.765 |
0.001 |
0.26 |
0.028 |
0.005 |
0.115 |
| rs7616006 |
3:12267648 |
SYN2 |
G/A |
0.43 |
0.705 |
0.385 |
0.181 |
0.36 |
0.974 |
0.959 |
0.836 |
| rs761772 |
17:76122078 |
TMC6 |
C/T |
0.13 |
0.077 |
0.109 |
0.009 |
0.13 |
0.480 |
0.361 |
0.861 |
| rs7756992 |
6:20679709 |
CDKAL1 |
G/A |
0.27 |
0.180 |
0.094 |
0.292 |
0.42 |
0.856 |
0.997 |
0.995 |
| rs8192675 |
3:170724883 |
SLC2A2 |
C/T |
0.30 |
5.4E-05 |
6.1E-05 |
0.010 |
0.29 |
0.232 |
0.239 |
0.024 |
| rs837763 |
16:88853729 |
CDT1 |
C/T |
0.44 |
0.591 |
0.804 |
0.046 |
0.56 |
0.492 |
0.554 |
0.533 |
| rs857691 |
1:158626378 |
SPTA1 |
T/C |
0.25 |
0.803 |
0.492 |
5.6E-06 |
0.30 |
0.092 |
0.226 |
0.894 |
| rs9604573 |
13:114542858 |
GAS6 |
A/G |
0.26 |
0.482 |
0.300 |
0.687 |
0.24 |
0.902 |
0.833 |
0.425 |
| rs9818758 |
3:49382925 |
USP4 |
A/G |
0.17 |
0.240 |
0.870 |
0.780 |
0.09 |
0.297 |
0.297 |
0.642 |
| rs9914988 | 17:27183104 | ERAL1 | G/A | 0.21 | 0.307 | 0.993 | 0.058 | 0.66 | 0.252 | 0.080 | 0.342 |
freq, frequency. Candidate SNPs selected from NHGRI database based on previous genome-wide significant associations. P values that reach study-wide significance for fructosamine and glycated albumin, P < 2.7 × 10−4 (0.05/(2*2*46)), and P values that reach nominal significance (P < 0.05) for HbA1c are in boldface type.