Table 1.

Summary of recent findings investigating behavioral sex differences in ketamine response.

Measure	Mode of delivery	Behavioral outcome	Citations
Forced-swim test	acute, IP	♀ respond to lower dose than ♂; estrus cycle-dependent	8, 9, 10, 11, 14
Forced-swim test	repeated, IP	♀ prodepressive; ♂ antidepressant	15
Novelty-suppressed feeding	acute, IP	♀ respond to lower dose than ♂	8
Sucrose preference test	acute + repeated, IP	mixed/conflicting results; hormone-dependent	8, 9, 14, 19
Locomotor sensitization	repeated, IP	♀ respond to lower dose than ♂	26, 27
Conditioned place preference/avoidance	repeated, IP	mixed/conflicting results, dose-dependent	26, 27, 28
Self-administration	repeated, IV	♀ in proestrus similar to ♂, but diestrus lower than either.	30

IP, intraperitoneal; IV, intravenous;